Lodenafil carbonate tablets: optimization and validation of a capillary zone electrophoresis method

Lodenafil Carbonate Tablets: Optimization and Validation of a Capillary Zone Electrophoresis Method

Um método simples de eletroforese capilar de zona (CZE) foi desenvolvido e validado para análise de carbonato de lodenafila em comprimidos. A metodologia de superfície de resposta foi utilizada para a otimização do pH, concentração do tampão, voltagem e temperatura. O método utilizou como eletrólito, tampão borato 50 mmol L, pH 10, voltagem de 15 kV. A separação foi efetuada em capilar de sílic...

Validated Method for the Determination of Piroxicam by Capillary Zone Electrophoresis and Its Application to Tablets

Simple and rapid capillary zone electrophoretic method was developed and validated in this study for the determination of piroxicam in tablets. The separation of piroxicam was conducted in a fused-silica capillary by using 10 mM borate buffer (pH 9.0) containing 10% (v/v) methanol as background electrolyte. The optimum conditions determined were 25 kV for separation voltage and 1 s for injectio...

A stability indicating capillary electrophoresis method for analysis of buserelin

A simple and rapid stability indicating method based on capillary zone electrophoresis has been developed and validated for the analysis of buserelin (BUS). The best separations were achieved by using a bare fused silica capillary (75 m i.d.; 65.5 cm total, 57.0 cm effective length), phosphate buffer (pH = 3.00; 26.4 mM), at 35 °C. The sample was hydrodynamically injected at 50 mbar for 5 seco...

Method development and validation of capillary electrophoresis: A practical aspect

The current review illustrates the method development and validation of capillary electrophoresis (CE) from experiences of the author research group. Various examples including drug monitoring, pharmaceutical, and natural product analyses are described. The author emphasizes that no specific CE condition is applicable for all problems. Analytes’ physicochemical properties (e.g., solubility, dis...

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